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In the current study the group on Dr Kristina Schoonjans and Prof. Johan Auwerx in in examining the role of TGR5 the intestine when TGR5 is expressed as at cells of specialized in during the production of intestinal-derived hormones. The authors found that these so-called enteroendocrine cells TGR5 manages which secretion of a hormone Glucagon-Like Peptide-1 , that. A critical role in overseeing pancreatic functional and regulation blood sugar levels In addition to this discovery, and in collaboration with Prof. Roberto Pellicciari that was developed a novel more potent and selective TGR5 activator, INT 777 below a long-standing collaboration with Intercept Pharmaceuticals, the group the EPFL showed that under laboratory conditions, this compound effective be treated diabetes and reduce fatty weight. GLP – also showed that that action were related to at the increase in both GLP – 1 secretion and energy costs.

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