Reference: E Castigli et al.

Reference: E Castigli et al. TACI is mutant in common variable immunodeficiency and IgA deficiency. Nature Genetics 37:829-34 . DOI: 10.1038/ng1601.

Senior author of the study and the James Gamble Professor of Pediatrics at Harvard Medical School. ‘Many children who are sick with this disease now missed, normal normal IgA and IgG levels, but they still have poor antibody responses and the same bacteria and viruses again and again. ‘ – But the discovery of genes not immediately change treatment strategies, says Dr. ‘For the time being, therapy still consists of prophylactic antibiotics or intravenous immunoglobulin infusions every three weeks,’he says.. Because TACI mutations are genetically dominant, a person with TACI mutations is one of the two TACI genes he or she inherits unable to mount a strong antibody response. Each child of a person so affected has 50 % chance of 50 % chance mutation and provided to, IgA deficiency and CVID. – ‘A test for TACI defects would diagnosis diagnosis of children and their relatives with this immune,’says Dr. Continue reading “Reference: E Castigli et al.”