To SHM SHM has a wide spectrum of mutations to produce, Such ahers conducted a gene encoding a red fluorescent protein into a human B cell cancer line, called Ramos, the immunoglobulin genes mutated by SHM. The gene for the fluorescent protein is an ‘off-switch’the antibiotic activated by the antibiotic doxycycline was fitted so could the researchers. Control its activity in the cells Since SHM affects only active genes, this technique allows the researchers, the rate of mutation of the gene introduced.
The researchers goal was to induce SHM, new versions of the red fluorescent protein develop that would be useful in the laboratory. Especially they hoped one molecule that fluoresces at longer wavelengths than the original stimulated by stimulated by creating laser light. Such a fluorescent protein would help researchers use fluorescent proteins in intact mammals, because they absorb and emit light in the red by by the blood. Continue reading “To SHM SHM has a wide spectrum of mutations to produce.”