The glandular tissue of the breast contains two cell types, outer basal cells and inner luminal cells. The basal layer is composed predominantly of differentiated cells with a small population of breast stem cells. Luminal layer contains differentiated cells and different types of cells, the intermediate stages between the luminal and stem cells. The different cell types can be identified and isolated on the basis of specific molecular markers.
‘In breast cancer, it has been proposed that different tumor subtypes may stem and stem and intermediate cells, with more aggressive ‘ basal-like’breast, What is striking is stem cells and less aggressive breast cancers from the luminal intermediates explains senior study author, Matthew J. Smalley from The Breakthrough Breast Cancer Research Centre at the Institute of Cancer Research in London. ‘Strikingly, the vast majority of breast tumors with mutations in BRCA1, a breast cancer susceptibility gene, basal-like characteristics, which have a stem cell origin. ‘. Continue reading “The glandular tissue of the breast contains two cell types.”