Hypertrophic cardiomyopathy.

The Mount Sinai team took patient skin cells and reprogrammed them pluripotent stem cells. Such cells can in almost any type in almost any type of cell in the human body. The researchers then cardiac cells, created the characteristics of hypertrophic cardiomyopathy. We knew, there was in the use of human pluripotent stem cells with genetic disorders, diseases in vitro potential to develop, but our study is the first to successfully create abnormal heart cells, said the principal investigator of the study Ihor R. Lemischka, Professor, Gene and Cell medicine, Developmental Biology and Regenerative Biology, Mount Sinai School of Medicine. Where we developed these cells, we can examine why they are enlarged and develop applications, to prevent them from clogging. – Scientists know that genetic disorders occur because of a mutation in a protein signaling pathway called the RAS pathway, but they were not able to exactly how these results determined in disease-associated problems such as hypertrophic cardiomyopathy.

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