However, when the researchers stopped these cells from production RNF4 by arsenic to the collapse to the collapse of the PML fusion protein, but the built-tagged SUMO PML fusion protein into the nucleus of the cell. Cells, when PML RNF4 these arsenic-treated cells, the PML broken broken down as normal.
What were the findings?The researchers found that the continuation of the cells in the production of a structure resulted RNF4 SUMO labeled PML fusion protein in the cells, because it is not broken properly. They also found that RNF4 only the PML fusion protein for degradation it it were SUMO molecules bound. They found that the treatment of cells with the addition of arsenic lead to the SUMO molecules to the PML fusion protein and degradation of the fusion protein PML. Continue reading “But the built-tagged SUMO PML fusion protein into the nucleus of the cell.”